industrial or household grade cyanoacrylate is made of shorter alkyl
chain derivatives such as methyl or ethyl cyanoacrylate (WPI's #7341
and #7342). They are very useful for temporarily holding tissues such
as mounting specimens for microtome sectioning. However, they are not
suitable for bonding wounds on live animals. The difficulties of using
cyanoacrylate for bonding live animals are: (1) a strong, irritating odor;
(2) quick loss of bonding strength due to breakdown of the bonding by
hydration; (3) the breakdown products, cyanoacetate and formaldehyde,
are toxic and can cause inflammatory reactions; and (4) they have low
flexibility and tend to be brittle.
is butyl cyanoacrylate. This
product has been used
for animal and human
applications outside the USA
since 1970. It is much less
toxic and has a lower odor
than the methyl or ethyl
cyanoacrylate. The butyl
cyanoacrylate offered by
WPI is VetbondTM.
stabilizer, was developed In the 1990's (one of them
approved by FDA for human use). When bonding to
tissue, these new adhesives are four times stronger
and less toxic than butyl cyanoacrylate. Compared
the new super adhesive
has several advantages.
On average, it takes only
one-tenth of the time
to close an incision. The
bonding strength is equal
to 5-0 monofilament suture.
It also has a mysterious
antimicrobial effect that
can decrease infection rates
in contaminated wounds.
Bonding will slough off
naturally in 5 to 7 days.
Cosmetic appearance of the
healed incision is also better.
holding a sensor or other device on the tissue. Setting time is about 10
seconds, which gives ample time for application. It can also be used for
temporarily holding a live tissue. For example, there is a report of using it
to hold nematodes on a glass slide for patch-clamp neurons recording.
they are not sterile and do not have FDA approval.
dissecting pads easily and
quickly. Mix the 2-part sili-
cone right in the plastic petri
dishes and allow to cure 24
hours at room temperature.
Kit includes enough silicone
to prepare 20 dishes.
pot ting and en cap su lat ing applications.
Very low di elec tric constant sealing com-
pound used in patch clamp ing and many
other lab applications. After cure, will
with stand -55° to 200 °C.
proof adhesion to bond tissue in a variety of vet procedures. Comes in 3g
dispensing bottles with five applicators.