DAM80

Overview

Benefits

• Very low internal noise
• Ultra quiet DC power supply ­— no AC required
• Intrinsic low susceptibility to ground loops
• Small footprint
• Cost-effective
• Electrostatic Discharge?Protection!

Applications

• Amplifying biopotentials from metal electrodes
• Brain slice field stimulation
• EAG (Electroantennogram)
• ERG (Electroretinogram)

DAM80 Features

• Battery powered to eliminate line noise
• High pass and low pass filtering
• Single ended or differential operation
• AC amplification only
• Includes low-noise headstage
• Variable output positioning
• Constructed of high quality components to ensure minimal intrinsic (shot) noise
• Portable
• Rack mountable

WPI’s DAM series amplifier’s are well known as a standard of the industry for extracellular potential amplification. These battery powered bio-amplifiers are designed with a compact chassis profile that enables the user to locate the unit closer to the preparation and thereby minimize long lead lengths which contribute to noise. Each amplifier is equipped with selectable high and low filters, and a position control to offset galvanic potentials which may develop during recording. A choice of models offer additional features that are useful for certain applications. The startup kit (included) is shown in the image. 

DAM80 startup kit includes

• CBL102 Cable, BNC-to-3.5mm plug, 6 ft (2m) (two)
• 5469 Adapter, mini-banana to 0.031 skt. (two)
• 13388 Adapter, mini-banana to 2mm skt. (two)
• 3294 Cable, ground clip to wire, 3 ft
• 2033 Mini-banana plug, black
• 2034 Mini-banana plug, red
• 2035 Mini-banana plug solderable turrent (two)
• EP1 Ag/AgCl pellet (70 mm wire) 1mm diam x 2.5 mm long
• M3301EH Electrode Holder, 14cm (two)
• 5470 0.031-inch jack on 12-inch wire (package of 4)

Current Generation

The DAM80 is perfect for gated or manual current generation for histological marking, iontophoresis or cell stimulation. It includes a very low noise remote active headstage that is useful for very high impedance amplification utilizing glass or metal electrodes.

Remote active headstage

DAM80, an AC amplifier only, features a very low noise headstage probe which can be mounted in micromanipulators for up-close cortical recording, for extracellular recording from high impedance glass or metal microelectrodes. Also provides a gated current for tissue marking.

Portability

DAM series amplifiers can be used as standalone units on any tabletop, or use optional clamp-mounting hardware to locate them conveniently within the work area. Alternatively, a pair of amplifiers can be mounted into a standard equipment rack with a rack mount kit (#3484 ). A variety of hook up accessories are available to configure your application

Feature Comparision Chart

	DAM50	DAM80
Input Mode	AC/DC	AC
Input Configuration	Differential/Single Ended	Differential
Gain Range	100-10,000 (AC) 10-1,000 (DC)	100 - 10,000 (AC)
High/Low Filters	Yes	Yes
Offset Position Control	Yes	Yes
Current Generator	No	Yes
Remote Active Headstage	No	Yes
Output Connection	BNC	3.5 mm mini phone
Standard Input Connection	unterminated wire	Mini banana
Power Supply	(2) 9V alkaline batteries	(2) 9V alkaline batteries

 

 

Specifications

INPUT IMPEDANCE	1012 Ω, common mode and differential
INPUT LEAKAGE CURRENT	50 pA (typical)
COMMON MODE REJECTION RATIO	100 dB @ 50/60 Hz
INPUT CAPACITANCE	20 pF
AC MODE NOISE	0.4 µV RMS (2uV p-p) 0.1-100 Hz
AC MODE NOISE	2.6 µV RMS (10uV p-p) 1Hz-10 kH
BANDWIDTH FILTER SETTINGS, AC Mode	Low frequency, 0.1, 1, 10, 300 Hz
BANDWIDTH FILTER SETTINGS: AC Mode(DAM80)	High frequency, 0.1, 1, 3, 10 kHz
OUTPUT CONNECTORS	3.5 mm MiniPhone connector on DAM80
OUTPUT VOLTAGE SWING	±8V
OUTPUT IMPEDANCE	470 Ω
BATTERY TEST	Audible tone
CALIBRATOR SIGNAL	10 Hz square wave
POSITION	Approximately 250 mV
CURRENT SOURCE:DAM80: DC Generator	0 to ±50 µA, variable
EXTERNAL COMMAND	Input Voltage ±10 V commands
AC or DC current waveform	±50 µA max. amplitude @ 200 Ω
BATTERIES	2 x 9 V alkaline (included)
DIMENSIONS:DAM80	17.8 x 10.2 x 4.4 cm
SHIPPING WEIGHT	1.6 kg

Accessories

Citations

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Orton, L. D., Papasavvas, C. A., & Rees, A. (2016). Commissural Gain Control Enhances the Midbrain Representation of Sound Location. The Journal of Neuroscience?: The Official Journal of the Society for Neuroscience, 36(16), 4470–81. http://doi.org/10.1523/JNEUROSCI.3012-15.2016

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Feng, B., & Gebhart, G. F. (2015). In vitro Functional Characterization of Mouse Colorectal Afferent Endings. Journal of Visualized Experiments, (95), e52310–e52310. http://doi.org/10.3791/52310

Gholami, M., Moradpour, F., Semnanian, S., Naghdi, N., & Fathollahi, Y. (2015). Chronic sodium salicylate administration enhances population spike long-term potentiation following a combination of theta frequency primed-burst stimulation and the transient application of pentylenetetrazol in rat CA1 hippocampal neurons. European Journal of Pharmacology, 767, 165–174. http://doi.org/10.1016/j.ejphar.2015.10.021

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Hermann, P. M., Park, D., Beaulieu, E., & Wildering, W. C. (2013). Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges. BMC Neuroscience, 14(1), 83. http://doi.org/10.1186/1471-2202-14-83

Kam, T.-I., Song, S., Gwon, Y., Park, H., Yan, J.-J., Im, I., … Jung, Y.-K. (2013). FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease. The Journal of Clinical Investigation, 123(7), 2791–802. http://doi.org/10.1172/JCI66827

Park, H.-J., Bonmassar, G., Kaltenbach, J. A., Machado, A. G., Manzoor, N. F., & Gale, J. T. (2013). Activation of the central nervous system induced by micro-magnetic stimulation. Nature Communications, 4, 2463. http://doi.org/10.1038/ncomms3463

Sanchez-Jimenez, A., Torets, C., & Panetsos, F. (2013). Complementary processing of haptic information by slowly and rapidly adapting neurons in the trigeminothalamic pathway. Electrophysiology, mathematical modeling and simulations of vibrissae-related neurons. Frontiers in Cellular Neuroscience, 7, 79. http://doi.org/10.3389/fncel.2013.00079

Sotoyama, H., Namba, H., Chiken, S., Nambu, A., & Nawa, H. (2013). Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling. Journal of Neurochemistry, 126(4), 518–28. http://doi.org/10.1111/jnc.12223

Jirakulsomchok, D., Napawachirahat, S., Kunbootsri, N., Suttitum, T., Wannanon, P., Wyss, J. M., & Roysommuti, S. (2012). Impaired renal response to portal infusion of hypertonic saline in adriamycin-treated rats. Clinical and Experimental Pharmacology and Physiology, 39(7), 636–641. http://doi.org/10.1111/j.1440-1681.2012.05722.x

Kato, Y. X., Furukawa, S., Samejima, K., Hironaka, N., & Kashino, M. (2012). Photosensitive-polyimide based method for fabricating various neural electrode architectures. Frontiers in Neuroengineering, 5. http://doi.org/10.3389/fneng.2012.00011

Ohnami, S., Kato, A., Ogawa, K., Shinohara, S., Ono, H., & Tanabe, M. (2012). Effects of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fibre-evoked field potentials in spinal long-term potentiation and neuropathic pain. British Journal of Pharmacology, 167(3), 537–47. http://doi.org/10.1111/j.1476-5381.2012.02007.x

Razy-Krajka, F., Brown, E. R., Horie, T., Callebert, J., Sasakura, Y., Joly, J.-S., … Vernier, P. (2012). Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory. BMC Biology, 10(1), 45. http://doi.org/10.1186/1741-7007-10-45

Hu, W., Bi, Y., Zhang, K., Meng, F., & Zhang, J. (2011). High-frequency electrical stimulation in the nucleus accumbens of morphine-treated rats suppresses neuronal firing in reward-related brain regions. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 17(6), BR153-60. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3539543&tool=pmcentrez&rendertype=abstract

Kim, J.-E., & Kang, T.-C. (2011). The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice. Journal of Clinical Investigation, 121(5), 2037–2047. http://doi.org/10.1172/JCI44818

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Schwarz, D., Bloom, D., Castro, R., Pagán, O. R., & Jiménez-Rivera, C. A. (2011). Parthenolide Blocks Cocaine’s Effect on Spontaneous Firing Activity of Dopaminergic Neurons in the Ventral Tegmental Area. Current Neuropharmacology, 9(1), 17–20. http://doi.org/10.2174/157015911795017010

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