Overview

• Biaxial stimulation of a cells in a monolayer or 3D matrix

 

The MCB1 uses a complex deformable interface to generate radial motion patterns on a 24-pin mounting ring.  User-supplied 35mm diameter membranes, scaffolds, and tissues can be puncture-mounted to this ring and biaxially stretched according to the specified protocol.  The entire assembly can be sterilized and is suitable for long-term cell culture in a laboratory incubator.

Key Features

 

• Biaxial stretch up to 20%
• Compatible with a wide range of materials including silicone membranes, decellularized tissues, hydrogels, electrospun materials, and more.
• PC-independent operation
• User-friendly interface software for specifying simple, cyclic, and intermittent stimulation protocols for download to the device controller

 

Specifications

Dimensions	22 X 10 X 4cm
Weight	1 kg
Stimulation Mode	Biaxial tension
Configuration	Cell monolayer, 3D constructs and tissues
Culture Area	1 well, 35mm diameter
Maximum Strain	20% biaxial
Maximum Velocity	10mm/s
Maximum Cycle Frequency	2Hz
Loading Capacity	10N
Media Volume/well	0.5-100mL

Accessories

Citations

Rashika Joshi, Matthew R. Batie, Qiang Fan, and Brian Michael Varisco* (2021). Mouse Lung Organoid Responses to Reduced, Increased, and Cyclic Stretch. American journal of physiology. Lung cellular and molecular physiology vol. 322,1 (2022): L162-L173. doi:10.1152/ajplung.00310.2020

Xun Xu, Yan Nie, Weiwei Wang, Nan Ma & Andreas Lendlein  (2021). Periodic thermomechanical modulation of toll-like receptor expression and distribution in mesenchymal stromal cells. MRS communications, 1-7. 8 Jul. 2021, doi:10.1557/s43579-021-00049-5

Kim, M.K.M., Burns, M.J., Serjeant, M.E. and Séguin, C.A., (2020). The mechano-response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent. JOR spine vol. 3,4 e21114. 20 Jul. 2020, doi:10.1002/jsp2.1114

O. Friedrich, A-L. Merten, D. Schneidereit, Y. Guo, S. Schurmann, N. Martinac (2019). Stretch In Focus: 2d Inplane Cell Stretch Systems For Studies Of Cardiac Mechano-Signaling. Frontiers in bioengineering and biotechnology vol. 7 55. 27 Mar. 2019, doi:10.3389/fbioe.2019.00055

K. Chen, A. Vigliotti, M. Bacca, R. M. McMeeking, V.S. Dashpande, J.W. Holmes (2018). Role Of Boundary Conditions In Determining Cell Alignment In Response To Stretch. Proceedings of the National Academy of Sciences of the United States of America vol. 115,5 (2018): 986-991. doi:10.1073/pnas.1715059115

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