Millipore Millicell Compatibility
The EVOM™ Manual has been designed to improve workflow efficiency when working with Millipore MilliCell® cell culture insert plates, delivering increased stability, and providing more repeatable measurements than older Trans Epithelial Electrical Resistance (TEER) meters including the Millipore MilliCell; ERS-2, Millipore MilliCell ERS and World Precision Instruments EVOM2.
For over 30 years, World Precision Instruments has been perfecting equipment for measuring Transepithelial Electrical Resistance (TEER). Researchers have relied on WPI's EVOM™ technology for the development of well over 16,000 peer-reviewed published research papers that use WPI TEER measurement meters. Here we compare the commonly used TEER meters in laboratories today. At a glance you can see the evolution of WPI's TEER technology and learn why it is the industry's standard TEER measurement methodology. Here's some of the benefits of upgrading to the EVOM™ Manual vs the MilliCell ERS voltohmmeter.
Comparison of EVOM™ Manual vs Millipore MilliCell ERS-2
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EVOM2 Epithelial Volt Ohm Meter |
MilliCell® ERS-2 Voltohmmeter MERS00002 |
EVOM™ Manual TEER Measurement Meter |
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Tissue Sampling Frequency |
12.5Hz | 12.5Hz | 12.5Hz |
| Resistance Range Modes | 0 to 9,999 Ω | 0 to 9,999 Ω |
0 to 10,000 Ω |
| AC Square Wave Current |
±10 µA |
±10 µA |
±10 µA for 10,000 Ω Range |
| Electrode Connection | RJ-11 Connector STX Electrode Included |
RJ-11 Connector STX Electrode Included |
Mini XLR Connector |
| Membrane Voltage Range | ±200.0 mV Voltage Resolution= 0.1 mV |
±200.0 mV Voltage Resolution= 0.1 mV |
±200.0 mV |
| Unit Warmup Time | 20 min. | 20 min. |
Ready for immediate use |
| Resistance Mode for TEER |  |
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PD (mV) Mode for Active Transport Studies |
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| Compact, Lightweight & Portable | |
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| Non-Invasive Measurement with EVOM™ Technology |
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| Smart Touchscreen Controls |
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| Selectable Resistance Range |
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| Auto Data Logging |
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| Hands-Free Operation |
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Benefits of EVOM™ Manual vs Millipore MilliCell ERS-2
More Stability/Accurate Readings
EVOM™ Manual gives you quick, easy, and reliable readings due to its fast stabilization, automatic twenty times sampling average, and low noise design. An overrange display feature eliminates erroneous readings.
Avoid the Need to Track Data by Hand
Millipore MilliCell ERS-2 requires you to log data by hand which is cumbersome and subject to transcription errors. EVOM™ Manual automatically captures the resistance or voltage readings to a USB drive in CSV format for easy access to your data, including date and time stamps on saved data. You can eliminate recording errors and reduce experimental processing time.
Variety of Measurement Ranges
Millipore MilliCell ERS-2 meters are limited to a single measurement range, but EVOM™ Manual allows you to select different ranges or can automatically detect the target range. Whether you are measuring a leaky cell type with low resistances or cell types for which barrier function is critical and resistance is higher, like blood brain barrier (BBB), the EVOM™ Manual can auto select. The auto-ranging resistance feature allows for fast resistance measurements. The EVOM™ Manual now has adjustable current levels in three fixed ranges with two lower ranges for sensitive membranes and high resistance ranges up to 100K Ω, making the EVOM™ Manual suitable for a variety of cell and tissue culture types (skin, intestine), complex 2-D (co-culture) or 3-D model (BBB) applications.
Hands Free Recording
With EVOM™ Manual you can streamline your process with a footswitch for hands-free recording, making sample analysis even faster. Data is recorded automatically, every time you tap the footswitch. You also minimize the chance of sample contamination when you limit hand movement during operation.
Touchscreen Display
EVOM™ Manual has an intuitive touchscreen controller with and easy-to-navigate menu and a graphical display showing your data for vital feedback during experimental measurements. The Millipore MilliCell ERS-2 show a simple numerical reading. With the EVOM™ Manual, you see the data for all the plate samples.
Millipore Plate Compatibility With EVOM™ Manual
The EVOM™ Manual requires an electrode for use. Choose an electrode suitable for your application.
Millicell Standing Inserts
| Millipore Plate | Compatible TEER Electrode | Device Configuration | Description |
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PSHT004 PSHT004R1 PSHT004R5 PSHT004S5 |
96-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 0.4 µm Filtration Area: 0.11 cm² |
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PSRP004 PSRP004R1 PSRP004R5 |
96-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 1.0 µm Filtration Area: 0.11 cm² |
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| PIHP01250 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 0.4 µm Filtration Area: 0.6 cm² |
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PSHT010R PSHT010R1 PSHT010R5 |
STX4 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 0.4 µm Filtration Area: 0.7 cm² |
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PICM01250 |
24-well plate |
Chemistry & Media: Hydrophilic Polytetrafluoroethylene (PTFE) / Biopore Pore Size: 0.4 µm Filtration Area: 0.6 cm² |
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PIHA01250 |
24-well plate |
Chemistry & Media: Mixed Cellulose Esters (MCE) / MF-Millipore Pore Size: 0.45 µm Filtration Area: 0.6 cm² |
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PSRP010 PSRP010R1 PSRP010R5 |
24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 1.0 µm Filtration Area: 0.7 cm² |
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PITP01250 |
24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 3.0 µm Filtration Area: 0.6 cm² |
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PSST010R PSST010R1 PSST010R5 |
STX4 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 3.0 µm Filtration Area: 0.7 cm² |
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PSMT010R PSMT010R1 PSMT010R5 |
STX4 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 5.0 µm Filtration Area: 0.7 cm² |
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PI8P01250 |
STX4 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 8.0 µm Filtration Area: 0.6 cm² |
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PSET010 PSET010R1 PSET010R5 |
STX4 | 24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 8.0 µm Filtration Area: 0.7 cm² |
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PIXP01250 |
24-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 12.0 µm Filtration Area: 0.6 cm² |
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| PICM0RG50 | Endohm-24 | 6-well plate |
Chemistry & Media: Hydrophilic Polytetrafluoroethylene (PTFE) / Biopore Pore Size: 0.4 µm Filtration Area: 4.2 cm² |
| PIHP03050 | Endohm-24 | 6-well plate |
Chemistry & Media: Polycarbonate (PC) / Isopore Pore Size: 0.4 µm Filtration Area: 4.2 cm² |
| PICM03050 | Endohm-24 | 6-well plate |
Chemistry & Media: Hydrophilic Polytetrafluoroethylene (PTFE) / Biopore Pore Size: 0.4 µm Filtration Area: 4.2 cm² |
| PIHA03050 | Endohm-24 | 6-well plate |
Chemistry & Media: Mixed Cellulose Esters (MCE) / MF-Millipore Pore Size: 0.45 µm Filtration Area: 4.2 cm² |
Millicell Hanging Inserts
| Millipore Plate | Compatible TEER Electrode | Device Configuration | Description |
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PTHT24H48 PCHT24H48 |
Endohm-6 | 24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 0.4 µm Filtration Area: 0.3 cm² |
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PTRP24H48 PLRP24H48 |
Endohm-6 | 24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 1.0 µm Filtration Area: 0.3 cm² |
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PTSP24H48 PCSP24H48 |
Endohm-6 | 24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 3.0 µm Filtration Area: 0.3 cm² |
| PTMP24H48 | Endohm-6 | 24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 5.0 µm Filtration Area: 0.3 cm² |
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PTEP24H48 |
Endohm-6 | 24-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 8.0 µm Filtration Area: 0.3 cm² |
| PTHT12H48
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EndOhm-12 | 12-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 0.4 µm Filtration Area: 1.1 cm² |
| PTRP12H48 | EndOhm-12 | 12-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 1.0 µm Filtration Area: 1.1 cm² |
| PTSP12H48 | EndOhm-12 | 12-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 3.0 µm Filtration Area: 1.1 cm² |
| PTMP12H48 | EndOhm-12 | 12-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 5.0 µm Filtration Area: 1.1 cm² |
| PTEP12H48 | EndOhm-12 | 12-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 8.0 µm Filtration Area: 1.1 cm² |
| PTHT06H48 | EndOhm-24 | 6-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 0.4 µm Filtration Area: 4.5 cm² |
| PTRP06H48 | EndOhm-24 | 6-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 1.0 µm Filtration Area: 4.5 cm² |
| PTSP06H48 | EndOhm-24 | 6-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 3.0 µm Filtration Area: 4.5 cm² |
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PTMP06H48
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EndOhm-24 | 6-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 5.0 µm Filtration Area: 4.5 cm² |
| PTEP06H48 | EndOhm-24 | 6-well plate |
Chemistry: Polyethylene Terephthalate (PET) Pore Size: 8.0 µm Filtration Area: 4.5 cm² |
EVOM™ Manual Electrodes
| Cell Culture Insert/Transwell Type | Electrode | Advantages | Disadvantages |
| Removable 24-well | STX4 | No need to transfer inserts. Take measurments in the plate. | |
| Removable 24-well | EndOhm-6 | Most accurate mode of measurement, because of the larger electrode surface area and the concentric positioning of the electrodes. | Need to transfer inserts into the EndOhm chamber for making measurements. |
| Removable 12-well | EndOhm-12 | ||
| Removable 6-well | EndOhm-24 | ||
| 24- or 96-well High Throughput Screening (HTS) Plates | STX HTS | Fits perfectly in the measurment plate. Choose the option based on your specific plate. |
While the EVOM™ Manual operates on the same proven EVOM™ technology as EVOM2 and Millipore MilliCell ERS-2, significant hardware and software upgrades provide exceptional new functionality to improve reading reliability and workflow efficiency. Give us a call today to talk with an application specialist.
Millicell is a registered trademark of Merck KGaA, Darmstadt, Germany
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