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Nicholas James, King's College London

Customer service was always quick and very helpful. Products all arrived quickly, were fully set up for us and have proved to be of good quality.
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Biotester-6000

Biotester-6000

BiOTESTER: A fully equipped biaxial test system built specifically for biomaterials, with increased force capacity up to 200N


  • Overview
  • Specifications
  • Accessories
  • Citations
  • Related Products

Overview

BioTester Biorakes with tissue mounted on a BioTester. The sample size is much smaller than a US penny

There are 2 images available to view - click to enlarge and scroll through the product gallery.

 

The BioTester provides researchers with an easy-to-use, affordable test instrument to characterize soft tissues and biomaterials. This biaxial test system captures and graphically displays live time, force, and synchronized video images for results analysis and verification. Data is easily exported to standard spreadsheet programs. 

  • High performance actuators (2 per axis) capable of μm positional resolution for accurate test motion.
  • Inline overload-protected load cell on each axis
  • High resolution CCD camera to collect time synchronized images for post test analysis
  • Temperature controlled media bath
  • Patented attachment system facilitates rapid and accurate specimen attachment
  • Optional use of hook-and-suture or grip based attachment systems
  • User-controlled test routines for multi-modal cyclic, simple, and relaxation testing over a wide range of strain rates
  • Data output as a comma separated value text files for easy import into a variety of spread sheet and data analysis programs
  • Simple USB connection to a Windows-based host computer
  • Specimen Size: 3mm to 15mm
  • Load Cell Capacities (N): 0.5, 1.5, 2.5, 5, 10, 23, 44, 110 or 200N
  • Load Cell Accuracies: 0.2% of capacity Max Displacement
  • Rate: 10mm/s Image Rate: 15Hz
  • Image Resolution: 2048 X 2048 pixels with CMOS camera
  • Max. Temperature: 45°C

Sample Mounting Systems

The BioRake sample mounting system is CellScale’s patented method for attaching soft tissues and biomaterials.

 Each tine is electrochemically sharpened to easily pierce both the toughest and most delicate tissue samples. Each set is permanently attached to a common base to allow simultaneous puncture of all 20 attachment points. The BioRakes are magnetically mounted for easy removal for cleaning or replacement and for simple transition between BioRake, Balanced Pulley, and Clamp mounting systems.

To perform testing, samples are positioned and raised into place using the manual lift mechanism and pressure is applied to insert the hooks in the tissue. The sample is thus mounted and ready for analysis within a few seconds. The mounting is consistent, accurate and easy.

BioRakes are available with tine spacing ranging from 0.7mm to 2.2mm to accommodate specimens from 3 to 15mm in size.

The balanced pulley sample mounting system is CellScale’s attachment method for ensuring zero shear stress during biaxial testing.

 

Two double-ended custom suture hooks are used to create 4 attachment points on each side of the specimen. A two-stage stainless steel pulley mechanism ensures that each of the sutures is held at the same tension during the test.

The pulley mechanisms are magnetically mounted for easy removal for cleaning and for simple transition between BioRake, Balanced Pulley, and Clamp mounting systems.

The clamp sample mounting system is CellScale’s attachment method for testing to failure.

 

Using a cruciform specimen allows the attachment sites, which are inherently weaker than the base material, to be moved away from the gauge area of the specimen. The clamps allow the specimen to be loaded easily and held securely.

The stainless steel clamping mechanisms are mounted over the same brackets used for the other attachment systems to allow for fast and easy transition between BioRake, Balanced Pulley, and Clamp mounting systems.

Custom clamp designs can also be made to tailor the clamp force and clamping surface to your tissue. 

Video Overviews 

 

Specifications

Force Capacity  0.5, 1.5, 2.5, 5, 10, 23, 44, 110, 200N
Force Accuracy  0.2% of force capacity
Max. Elongation Rate 10mm/s
Max. Strain Rate (5mm specimen) 200%/s
Spatial Resolution (Actuator)  >0.1μm 
Spatial Accuracy (Acuator) 10μm 
Spatial Resolution (Image Analysis)  1/8 pixel 
Max. Force Data Rate 100Hz
Image Rate 1280 x 960 -15Hz

Accessories

Citations

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Leonov, D. & Spirina, Yu & Yatsenko, A. & Kushnarev, Vladimir & Ustinov, E. & Barannikov, S. (2021). Advanced 3D Bioprinting Technologies. Cell and Tissue Biology. 15. 616-627. 10.1134/S1990519X21060134.

Borem, Ryan & Madeline, Allison & Theos, Chris & Vela, Ricardo & Garon, Alex & Gill, Sanjitpal & Mercuri, Jeremy. (2021). Angle-ply scaffold supports annulus fibrosus matrix expression and remodeling by mesenchymal stromal and annulus fibrosus cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 10.1002/jbm.b.34980.

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Lomboni, David & Steeves, Alexander & Schock, Sarah & Bonetti, Lorenzo & De Nardo, Luigi & Variola, Fabio. (2021). Compounded topographical and physicochemical cueing by micro-engineered chitosan substrates on rat dorsal root ganglion neurons and human mesenchymal stem cells. Soft Matter. 17. 10.1039/D0SM02170A.

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Hudson, Luke & Laurence, Devin & Lau, Hunter & Mullins, Brennan & Doan, Deenna & Lee, Chung-Hao. (2021). Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps. Journal of the Mechanical Behavior of Biomedical Materials. 125. 104907. 10.1016/j.jmbbm.2021.104907.

Surman, Tim & O'Rourke, Dermot & Reynolds, Karen & Edwards, J. & Worthington, M. (2021). M06 The Unique Tissue Biomechanics of the Thoracic Aorta. What are the Greatest Areas of Weakness and Where Should we Focus Repair?. Heart, Lung and Circulation. 30. S4. 10.1016/j.hlc.2021.03.015.

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Walsh, Darragh & Ross, Aisling & Newport, David & Zhou, Zhou & Kearns, Jamie & Fearon, Conor & Lorigan, Jennifer & Mulvihill, John. (2021). Mechanical Characterisation of the Human Dura Mater, Falx Cerebri and Superior Sagittal Sinus. Acta Biomaterialia. 134. 10.1016/j.actbio.2021.07.043.

Cunnane, Eoghan & Davis, NIALL & Cunnane, Connor & Lorentz, Katherine & Ryan, Alan & Hess, Jochen & Weinbaum, Justin & Walsh, Michael & O’Brien, Fergal & Vorp, David. (2021). Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold. Biomaterials. 269. 120651. 10.1016/j.biomaterials.2021.120651.

Maleckis, Kaspars & Kamenskiy, Alexey & Lichter, Eliezer & Oberley-Deegan, Rebecca & Dzenis, Yuris & Mactaggart, Jason. (2021). Mechanically Tuned Vascular Graft Demonstrates Rapid Endothelialization and Integration Into the Porcine Iliac Artery Wall. Acta Biomaterialia. 125. 10.1016/j.actbio.2021.01.047.

Morningstar, Jordan & Gensemer, Cortney & Moore, Reece & Fulmer, Diana & Beck, Tyler & Wang, Christina & Moore, Kelsey & Guo, Lilong & Sieg, Franz & Nagata, Yasufumi & Bertrand, Philippe & Spampinato, Ricardo & Glover, Janiece & Poelzing, Stephen & Gourdie, Robert & Watts, Kelsey & Richardson, William & Levine, Robert & Borger, Michael & Norris, Russell. (2021). Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. Journal of the American Heart Association. 10. 10.1161/JAHA.121.022332.

Ahmad, Dilshad & Ajaj, Rafic. (2021). Multiaxial Mechanical Characterization of Latex Skin for Morphing Wing Application. Polymer Testing. 10.1016/j.polymertesting.2021.107408.

Zheng, Cheng & Ding, Kailei & Huang, Xueyu & Li, Meiling & Wu, Bingang & Lei, Yang & Wang, Yunbing. (2021). Nonglutaraldehyde crosslinked bioprosthetic heart valves based on 2-isocyanatoethyl methacrylate crosslinked porcine pericardium with improved properties of stability, cytocompatibility and anti-calcification. Composites Part B: Engineering. 230. 109504. 10.1016/j.compositesb.2021.109504.

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Liu, Hailong & Jain, Shubham & Ahlinder, Astrid & Fuoco, Tiziana & Gasser, Thomas & Finne-Wistrand, Anna. (2021). Pliable, Scalable, and Degradable Scaffolds with Varying Spatial Stiffness and Tunable Compressive Modulus Produced by Adopting a Modular Design Strategy at the Macrolevel. ACS Polymers Au. XXXX. 10.1021/acspolymersau.1c00013.

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