SYS-A365R

Overview

The A365 is a specialized stimulus isolator for use in neuroscience and muscle studies. Battery operated and electrically isolated from ground, its quiet internal control circuitry minimizes artifacts and has very low leakage specifications. Stimulus isolation is needed to assure the precise localization of stimulus current and to prevent current flow from the stimulation site to ground.

Features

• Constant current
• Unipolar and bipolar stimulation modes
• Built-in non-compliance alarm
• Input is optically isolated
• Standard TTL triggering
• DC test mode
• Conventional logic-level commands
• Can be gated by any pulse generator, stimulator, or computer output
• Powered by rechargeable batteries (requires SYS-A362 battery recharger)
• Designed for neuroscience and muscle applications

Activated by conventional logic-level commands, Model A365 can be gated by any pulse generator, stimulator, or computer output with automated bipolar pulsing for zero net charge on biological preparations.

Benefits

• Compliance voltage is 100V or better
• Bipolar mode auto generates alternating positive and negative pulses from TTL input
• Test mode simplifies performance verification
• Optical isolation enhances safety of the preparation and reduces noise susceptibility

Applications

• Electrophysiology
• Brain slice stimulation
• In vivo brain and CNS stimulation

Dual Tone Audible Alarms

A tone sounds when an open electrode circuit is detected or when system compliance is reached. A second optional tone sounds when a signal is applied to the input. A test switch is also provided to check battery charge.

Current Delivery

Stimulus currents are set using a three-digit control knob and a three-position range switch. Output current tracks control set­tings to better than 1%. Output current is load independent; voltage sufficient to push the desired current through the load is automatically developed, subject only to compliance limits. Model A365 produces up to 10 milliampere current, in three ranges, at more than 100 volts compliance.

Polarity

Output polarity is determined by a three-position switch on the front panel (+/-/off).

Bipolar Pulsing

Output polarity is determined by a push switch on the front panel. Bipolar current is toggled by the command waveform, setting al­ter­nat­ing pulses as positive or negative.

Power

The rechargeable A365R is supplied with a nickel metal hydride battery stack. The A362 Battery Charger is required with the A365R. See A365RC, which includes both the A365R and the A362 battery charger.

 

NOTE: A365 is not intended for human use.

Specifications

OUTPUT WAVEFORM	DC or current pulse
OUTPUT CURRENT RANGES	0.1, 1.0, and 10 mA
CURRENT AMPLITUDE ERROR	0.5% of full scale, max.
CURRENT RESOLUTION	0.1% of full scale, typical
OUTPUT LOAD VOLTAGE EXCURSION (COMPLIANCE)	100V
EXTERNAL COMMAND THRESHOLD	5V at 3mA, min. 8.5V, max.
OUTPUT POLARITY	Reversible, manual switch or automatic
CURRENT RISE TIME & DELAY	6μs, typical (1KΩ load)
CURRENT FALL TIME & DELAY	10μs, typical (1KΩ load)
OUTPUT TO GROUND RESISTANCE	10^12Ω
OPTOCOUPLER	2500V, rated min. breakdown voltage
POWER: Model A365D (dry cell)	16 alkaline 9V batteries, included
POWER: Model A365R (rechargeable)	16 rechargeable NiMH 9 V batteries included
DIMENSIONS	8.5 x 3.5 x 5in. (22 x 9 x 12 cm)
SHIPPING WEIGHT	4 lb. (1.8 kg)

 

Accessories

Citations

Dalby-Brown, W., & Jessen, C. (2013). Characterization of a novel high-potency positive modulator of Kv 7 channels. European journal of  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S0014299913002574

Huda, R. (2013). pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract. Journal of  …. Retrieved from https://jn.physiology.org/content/early/2013/04/24/jn.01074.2012.abstract

Licko, T., Seeger, N., & Zellinger, C. (2013). Lacosamide treatment following status epilepticus attenuates neuronal cell loss and alterations in hippocampal neurogenesis in a rat electrical status epilepticus. …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1111/epi.12196/full

Schroder, E., & Lefta, M. (2013). The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility. American Journal of …. Retrieved from https://ajpcell.physiology.org/content/304/10/C954.short

Sonner, P., & Ladle, D. (2013). Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord. Journal of neurophysiology. Retrieved from https://jn.physiology.org/content/109/8/2118.short

Syvänen, S., Russmann, V., & Verbeek, J. (2013). quinidine and  laniquidar PET imaging in a chronic rodent epilepsy model: Impact of epilepsy and drug-responsiveness. Nuclear medicine and  …. Retrieved from https://www.sciencedirect.com/science/article/pii/S096980511300111X

Taib, N. O. Ben, & Manto, M. (2013). Trains of Epidural DC Stimulation of the Cerebellum Tune Corticomotor Excitability. Neural plasticity. Retrieved from https://www.hindawi.com/journals/np/2013/613197/abs/

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