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ISO-NOP007

ISO-NOP007

ISO-NOP007 Nitric Oxide Sensor - 7um


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Overview

ISO-NOP007

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Instruction Manual
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30 micron sensor with exceptional performance

The ISO-NOP007 has a tip diameter of 7 microns and a length of 2mm. The response is linear over a wide dynamic concentration range of NO. The design is based on a single carbon fiber coated with WPI's NO-selective membrane. A detection limit of approximately 1 nM NO makes these electrodes ideal for use in tissues and microvessels.

The response of a 7μm NO sensor (ISO-NOP007) to successive additions of NO (100nM). Inset shows the linearity of the resulting calibration plot.

Simultaneous measurement of force (top trace) and changes of NO concentration (lower trace) in (A) the rat superior mesenteric artery relaxed with ACh and (B) a small human artery relaxed with ACh and SNAP. In this artery oxyhaemoglobin (oxyHb) partly reversed the increase in NO concentration with only a small change in force. [U. Simonsen, et al., J. Physiol., 1999, 516: 271-282.]

 

Specifications

Outside Diameter  7μm
Available Length   2mm
Response Time   < 3 seconds  
Lowest Detection Limit/Range 0.5nM
Nominal Sensitivity-New sensor   ≥1pA/nM 
Baseline Drift   none
Poise Voltage  865mV
Typical Quiescent Baseline Current, 25°C 300pA
Acceptable Baseline Range   200-1500pA  
Polarization Time   1+ hours

 

Accessories

Citations

D.Z. Levine, M. Iacovitti,K.D. Burns, X. Zhang "Real-time profiling of kindey tubular fluid nitric oxide concentrations in vivo" Am J Physiol Renal Physiol Renal 281. 2001: F-189-F194

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