CW-MICROCAPSTAR
CO2 Analyzer for Small Animals- Overview
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Overview
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Data Sheet
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Manual
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- End-tidal peak or continuous readings
- Low sample flow requirements
- Accurate and stable monitoring
- Simple one-gas calibration
- Linear output signal for recording
The MICROCAPSTAR End-Tidal Carbon Dioxide Analyzer provides accurate end-tidal or continuous measurement of expired CO2 in animals as small as mice. It features very low sample flow requirements, rapid response time, and long-term stability. Respiratory rate (RR) is computed using the excursions of the CO2 waveform. The CO2 and RR measurements, as well as a trend plot of the end-tidal values, are displayed on the graphics LCD screen.
The heart of the MICROCAPSTAR is a new temperature-controlled, miniature infrared CO2 sensor with digital output. Low sample flow and rapid response is achieved with a carrier gas system employing digitally controlled active flow management. This technique precisely and automatically maintains the ratio of carrier flow to sample flow, which is essential for accurate measurements.
The heated measurement cell prevents water condensation, even during longterm measurement sessions. The front-panel display shows CO2 concentration (either instantaneous or ETCO2) in either percent or mmHg. Calibration is performed with a single calibration gas and room air. An adjustable ETCO2 alarm provides a warning when end-tidal values fall out of a useradjustable preset range. All adjustments are performed digitally using a single knob. Built-in diagnostics monitoring warn of plugged sample tubing or other fault conditions.
The advanced features, reliability, and ease of operation of the MICROCAPSTAR make it the perfect companion to our SAR-830 series Small Animal Ventilators for monitoring respiratory status. An accessory pack containing spare low volume sample tubing and a variety of connectors and fittings is included with the instrument. A range of accessories is available to ensure easy setup and convenient operation. Windows-based monitoring software is included, which allows display of the measurements, and saving the data to a disk file.
Specifications
| CO2 Measurement | single beam, non-dispersive infrared |
| Measurement range | 0 - 9.9% (0 - 76.0mmHg) |
| CO2 Accuracy | 0.15% (1.1mmHg) |
| Resolution (internal and analog output) | 0.01% (0.1mmHg) |
| Resolution (display) | 0.1% (1.0mmHg) |
| Linearity | 0.1% CO2 |
| Repeatability | 0.1% CO2 |
| Response time (T10 - T90) | 75mS at 70 ml/min through cell |
| Sample cell materials | sapphire and stainless steel |
| Analog output scaling | 1.1V/% (0-10V) |
| Response time (T10 - T90) | 150mS at 50 ml/min sampling |
| Zero stability | 0.2% (8 hours), 0.3% (24 hours) |
| Interference effects: 50% N2O | 0.1% at 0% CO2, 0.6% at 5% CO2 (uncomp.) |
| Maximum sample cell pressure | +5 psig |
| Interference effects: vaporized anaesthetic agents | negligible |
| Operating temperature range | 5-40°C |
| Optical bench temperature | 48°C, controlled |
| Warm-up time | 4 min to 0.2%, 10 min to 0.1% |
| ETCO2 trend display | 5 minute graphical scrolling display |
| Sample flow (sample inlet - carrier flow out) | 10ml/min nominal, adjustable from 5.0 - 20ml/min |
| Sample tubing connections (carrier flow, sample inlet) | Luer female |
| Calibration controls | Zero, Span |
| ETCO2 alarm adjustment range | 1.0 - 9.9% (8 - 75mmHg) |
| Respiratory rate measurement range | 5 - 200 breaths/min |
| Signal outputs (rear panel) | BNC jacks |
| CO2 output scaling | 1.0V / %CO2 |
| Respiratory rate output scaling | 0.05V / bpm |
| Alarm output | 5V if alarm condition, 0V if no alarm |
| Serial data output format | 2400 baud, 8 data, no parity, 1 stop bit |
| Electrical requirements | 120VAC/220VAC switchable, 35VA |
| Dimensions | 19W x 5.25H x 16D in., 49W x 13H x 41D cm |
| Weight | 10 lbs. (4.5kg) |
Accessories
Citations
Kim, J., & Jeong, Y. (2013). Augmentation of Sensory-Evoked Hemodynamic Response in an Early Alzheimer’s Disease Mouse Model. Journal of Alzheimer’s Disease. Retrieved from https://iospress.metapress.com/index/H2KQ18756J7L5T37.pdf
Luckett, B., & Frielle, J. (2013). Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. American Journal of …. Retrieved from https://ajpheart.physiology.org/content/304/11/H1538.short
Perles-Barbacaru, T. (2012). Quantitative pharmacologic MRI in mice. NMR in …. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/nbm.1760/full
Sabino, J., Oliveira, M. de, & Giusti, H. (2013). Hemodynamic and ventilatory response to different levels of hypoxia and hypercapnia in carotid body-denervated rats. Clinics. Retrieved from https://www.scielo.br/pdf/clin/v68n3/a19v68n3.pdf
Sabino, J., Silva, C. da, & Giusti, H. (2013). Parasympathetic activation by pyridostigmine on chemoreflex sensitivity in heart-failure rats. Autonomic …. Retrieved from https://www.sciencedirect.com/science/article/pii/S1566070213006024
Shih, A., Driscoll, J., & Drew, P. (2012). Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of Cerebral …. Retrieved from https://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2011196a.html
Srienc, A., Kornfield, T., & Mishra, A. (2012). Assessment of glial function in the in vivo retina. Astrocytes. Retrieved from https://link.springer.com/protocol/10.1007/978-1-61779-452-0_33
Zhang, Z., Zhang, C., Zhou, M., & Xu, F. (2012). Activation of opioid μ-receptors, but not δ-or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats. Respiratory Physiology & Neurobiology. Retrieved from https://www.sciencedirect.com/science/article/pii/S1569904812001917
Zhuang, J., & Zhang, Z. (2012). 8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius. American Journal of …. Retrieved from https://ajpregu.physiology.org/content/303/4/R449.short
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